Fas and Fas-associated death domain protein regulate monocyte chemoattractant protein-1 expression by human smooth muscle cells through caspase- and calpain-dependent release of interleukin-1alpha

We previously reported that treatment of human vascular smooth muscle cells (SMCs) with proapoptotic stimuli, including Fas ligand plus cycloheximide (FasL/Chx), or overexpression of Fas-associated death domain protein (FADD) result in increased expression of monocyte chemoattractant protein-1 (MCP-...

Full description

Saved in:

Bibliographic Details
Published in:	Circulation research Vol. 93; no. 6; pp. 515 - 522
Main Authors:	Schaub, Friedemann J, Liles, W Conrad, Ferri, Nicola, Sayson, Kirsten, Seifert, Ronald A, Bowen-Pope, Daniel F
Format:	Journal Article
Language:	English
Published:	United States Lippincott Williams & Wilkins Ovid Technologies 19-09-2003
Subjects:	Adaptor Proteins, Signal Transducing Calpain - metabolism Calpain - physiology Carrier Proteins - metabolism Caspases - metabolism Caspases - physiology Cells, Cultured Chemokine CCL2 - biosynthesis Chemokine CCL2 - genetics Cycloheximide - pharmacology Fas Ligand Protein Fas-Associated Death Domain Protein Gene Expression Regulation Humans Interleukin-1 - biosynthesis Interleukin-1 - genetics Interleukin-1 - physiology Membrane Glycoproteins - pharmacology Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - enzymology Muscle, Smooth, Vascular - immunology Signal Transduction Transcription, Genetic - drug effects Up-Regulation
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!