Acute electroretinographic changes during sildenafil (Viagra) treatment for erectile dysfunction

The authors describe their findings on 12 subjects who were treated with 50 mg of sildenafil (Viagra) and underwent ERG measurements prior to and 1 hour after ingestion. The Naka-Rushton equation was used to describe the b-wave luminance-response function of the scotopic ERG. Statistically significa...

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Bibliographic Details
Published in:	Documenta ophthalmologica Vol. 107; no. 2; p. 111
Main Authors:	Balacco Gabrieli, Corrado, Regine, Federico, Vingolo, Enzo M, Rispoli, Edoardo, Isidori, Aldo
Format:	Journal Article
Language:	English
Published:	Netherlands Springer Nature B.V 01-09-2003
Subjects:	Electroretinography Erectile Dysfunction - drug therapy Erectile Dysfunction - physiopathology Humans Male Middle Aged Phosphodiesterase Inhibitors - adverse effects Piperazines - adverse effects Purines Retina - drug effects Retina - physiopathology Sildenafil Citrate Sulfones Time Factors
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Summary:	The authors describe their findings on 12 subjects who were treated with 50 mg of sildenafil (Viagra) and underwent ERG measurements prior to and 1 hour after ingestion. The Naka-Rushton equation was used to describe the b-wave luminance-response function of the scotopic ERG. Statistically significant differences were noted in the Vmax and K values. Sildenafil ingestion resulted in an increase in Vmax (higher rod response to light stimuli) and a decrease in K (higher sensitivity).
ISSN:	0012-4486 1573-2622