A method of obtaining starting values of kin and kout for the indirect response models
A method based on the multivariate technique known as principal component analysis is proposed to obtain starting values for the rate constants of indirect response models. The method is not iterative and only requires standard deviation calculations for two quantities, which are simple functions of...
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| Published in: | Journal of pharmacokinetics and pharmacodynamics Vol. 31; no. 1; pp. 29 - 42 |
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| Main Authors: | , |
| Format: | Journal Article |
| Language: | English |
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Dordrecht
Springer
01-02-2004
Springer Nature B.V |
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| Abstract | A method based on the multivariate technique known as principal component analysis is proposed to obtain starting values for the rate constants of indirect response models. The method is not iterative and only requires standard deviation calculations for two quantities, which are simple functions of the measured pharmacodynamic response. An algorithm is provided which can be implemented in a spreadsheet. The methodology is justified theoretically herein, nevertheless, two examples are provided to illustrate the method and demonstrate its viability.[PUBLICATION ABSTRACT] |
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| AbstractList | A method based on the multivariate technique known as principal component analysis is proposed to obtain starting values for the rate constants of indirect response models. The method is not iterative and only requires standard deviation calculations for two quantities, which are simple functions of the measured pharmacodynamic response. An algorithm is provided which can be implemented in a spreadsheet. The methodology is justified theoretically herein, nevertheless, two examples are provided to illustrate the method and demonstrate its viability.[PUBLICATION ABSTRACT] |
| Author | MUKHERJEE, Debu HUTMACHER, Matthew M |
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| Copyright | 2004 INIST-CNRS Plenum Publishing Corporation 2004 |
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| DOI | 10.1023/B:JOPA.0000029487.21238.5c |
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| Keywords | pharmacodynamics indirect response models Pharmacology Method eigenvector Response Analysis Starting Value Models Component Pharmacokinetics starting values eigenvalue principal component analysis |
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| SubjectTerms | Biological and medical sciences Medical sciences Pharmacology. Drug treatments Principal components analysis Standard deviation Studies |
| Title | A method of obtaining starting values of kin and kout for the indirect response models |
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