Transcriptional effects of 1,25 dihydroxyvitamin D(3) physiological and supra-physiological concentrations in breast cancer organotypic culture

Vitamin D transcriptional effects were linked to tumor growth control, however, the hormone targets were determined in cell cultures exposed to supra physiological concentrations of 1,25(OH)(2)D(3) (50-100nM). Our aim was to evaluate the transcriptional effects of 1,25(OH)(2)D(3) in a more physiolog...

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Bibliographic Details
Published in:	BMC cancer Vol. 13; p. 119
Main Authors:	Milani, Cintia, Katayama, Maria Lucia Hirata, de Lyra, Eduardo Carneiro, Welsh, JoEllen, Campos, Laura Tojeiro, Brentani, M Mitzi, Maciel, Maria do Socorro, Roela, Rosimeire Aparecida, del Valle, Paulo Roberto, Góes, João Carlos Guedes Sampaio, Nonogaki, Suely, Tamura, Rodrigo Esaki, Folgueira, Maria Aparecida Azevedo Koike
Format:	Journal Article
Language:	English
Published:	England 15-03-2013
Subjects:	Breast Neoplasms - genetics Breast Neoplasms - metabolism Calcitriol - administration & dosage Calcitriol - pharmacology Carcinoma, Ductal, Breast - genetics Carcinoma, Ductal, Breast - metabolism Down-Regulation Epithelial Cells Female Fibroblasts Gene Expression Profiling Humans Oligonucleotide Array Sequence Analysis RNA - analysis Statistics, Nonparametric Tissue Culture Techniques Transcription, Genetic - drug effects Tumor Cells, Cultured Up-Regulation Vitamins - administration & dosage Vitamins - pharmacology
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