Efficient Synthesis of Trifluoromethyl Amines through a Formal Umpolung Strategy from the Bench-Stable Precursor (Me4N)SCF3

Reported herein is the one-pot synthesis of trifluoromethylated amines at room temperature using the bench-stable (Me4N)SCF3 reagent and AgF. The method is rapid, operationally simple and highly selective. It proceeds via a formal umpolung reaction of the SCF3 with the amine, giving quantitative for...

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Bibliographic Details

Published in:	Angewandte Chemie Vol. 129; no. 1; pp. 227 - 230
Main Authors:	Scattolin, Thomas, Deckers, Kristina, Schoenebeck, Franziska
Format:	Journal Article
Language:	English German
Published:	Weinheim Wiley Subscription Services, Inc 02-01-2017
Subjects:	Amines Chemistry Fluorides Functional groups Intermediates Reagents Room temperature Synthesis
Online Access:	Get full text
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