Validation of the PRIDE Scale (Primary Immunodeficiency Disease Evaluation) to Determine High Level of Suspicion for Primary Immunodeficiency Disease in Mexican Population

• Published in: Revista alergia Mexico (Tecamachalco, Pueblo, Mexico : 1993) Vol. 59; no. 4; pp. 192 - 198
• Main Authors: Mogica-Martínez, María Dolores, Velázquez-Leduc, Arturo, Ortega-Martell, José Antonio, Gómez-Alonso, Carlos, Rodriguez-Orozco, Alain R, Rico-Arroyo, Marisol, Becerril-Ngeles, Martín
• Format: Journal Article
• Language: Spanish
• Published: Mexico 01-10-2012
• Subjects: Cross-Sectional Studies; Early Diagnosis; Humans; Prevalence; Reproducibility of Results; Sensitivity and Specificity
• ISSN: 0002-5151

Primary immunodeficiencies have a low prevalence, but their severity and high risk of mortality require a clinical approach based in diagnostic instruments that allow their early detection.
To validate the PRIDE scale to determine a high level of suspicion for primary immunodeficiency diseases in Mexican population.
Seventy five patients with suspicion of primary immunodeficiencies (13.9 ±11.8 years-old) were evaluated with the PRIDE scale by specialists in Allergy and Immunology in this cross-sectional study, and their results were compared with the confirmed diagnosis of primary immunodeficiency.
Kappa concordance coefficient with clinical diagnosis was 0.872, with an standard error of 0.072; CI 95% [0.73-1.013]. The scale showed sensitivity 98.3%, specificity 86.6%, positive predictive value 96.7%, negative predictive value 92.8%, positive odds ratio 7.3358 and negative odds ratio 0.0196.
PRIDE scale was concordant with the diagnosis of primary immunodeficiency in the majority of patients with a previous confirmed diagnosis. The characteristics of diagnostic accuracy provide reliability to this instrument in the scrutiny of patients with probable immunodeficiency.