Effect of liraglutide on glucagon secretion in obese type 2 diabetic patients

• Published in: Chung-hua nei kʿo tsa chih Vol. 58; no. 1; p. 33
• Main Authors: Sun, X F, Wang, Y, Zhao, W J, Wang, L, Bao, D Q, Qu, G R, Yao, M X, Luan, J, Wang, Y G, Yan, S L
• Format: Journal Article
• Language: Chinese
• Published: China 01-01-2019
• Subjects: Blood Glucose - drug effects; Blood Glucose - metabolism; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - diagnosis; Diabetes Mellitus, Type 2 - drug therapy; Glucagon - drug effects; Glucagon - metabolism; Glucagon-Like Peptide 1 - administration & dosage; Glucagon-Like Peptide 1 - adverse effects; Glucagon-Like Peptide 1 - therapeutic use; Glycated Hemoglobin A - metabolism; Humans; Hypoglycemic Agents - administration & dosage; Hypoglycemic Agents - adverse effects; Insulin; Liraglutide - pharmacology; Obesity - complications; Postprandial Period - physiology; Prospective Studies; Treatment Outcome; Diabetes mellitus, type 2; Glucagon; Liraglutide
• ISSN: 0578-1426
• DOI: 10.3760/cma.j.issn.0578-1426.2019.01.006

To investigate the effect of liraglutide on glucagon release in obese type 2 diabetes (T2DM).
A multi-center, prospective, and self-comparison study was conducted in four hospitals in Qingdao. Twenty-four patients with T2DM were selected and treated with liraglutide for 12 weeks. Glucagon levels before and after treatment were detected before and 30 min, 60 min and 120 min after meals.
After 12 weeks of treatment, the overall level of glucagon decreased, in which the differences in glucagon levels at 30 min [(220±79) ng/L vs. (203±77) ng/L,
0.05] and 60 min [(248±119) ng/L vs. (203±82)ng/L,
0.05] reached significance, respectively, comparing to those before treatment. The area under the curve of glucagon after treatment was significantly lower than that before treatment (438±190 vs. 389±153,
0.05). In contrast, after treatment, the overall level of C-peptide increased, especially the levels at 30 min [(1.53±1.02) nmol/L vs.(2.03±1.29) nmol/L], 60 min [(1.93±1.19) nmol/L vs. (2.48±1.75) nmol/L] and 120 min [(2