EFFECT OF ANTIOXIDANTS ON ESOPHAGUS TISSUE REPAIR UPON EXPERIMENTAL CHEMICAL BURN FROM ACETIC ACID

This work is an experimental study on 30 rabbits to determine the effect of antioxidants on the process of repair of the esophagus. Chemical agent was 46% acetic acid, a The antioxidant "Mexidol" were injected to core group of test animals in 2 weeks. Animals were taken from the experiment...

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Bibliographic Details
Published in:	Ėksperimentalʹnaâ i kliničeskaâ farmacologiâ Vol. 78; no. 12; p. 26
Main Authors:	Klimashevich, A V, Nikol'skii, V I, Shabrov, A V
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 2015
Subjects:	Acetic Acid Animals Antioxidants - pharmacology Burns, Chemical - drug therapy Burns, Chemical - pathology Epithelium - drug effects Epithelium - injuries Esophagus - blood supply Esophagus - drug effects Esophagus - injuries Injections, Intramuscular Male Neovascularization, Physiologic - drug effects Picolines - pharmacology Rabbits Wound Healing - drug effects
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Summary:	This work is an experimental study on 30 rabbits to determine the effect of antioxidants on the process of repair of the esophagus. Chemical agent was 46% acetic acid, a The antioxidant "Mexidol" were injected to core group of test animals in 2 weeks. Animals were taken from the experiment at 5, 14, 21, 30, 45 and 60 hours. We conducted morphometric study of histological exemplars, determining the number of inflammatory cells, epithelial thickness, the area of newformed blood vessels. In the study group we reported an improvement of reparative processes in the wall of the body: it was increased blood supply to the burn surface on 242% and more rapid relief of inflammatory processes on 117% (p < 0.05).
ISSN:	0869-2092