Differences in the control of basal L-type Ca(2+) current by the cyclic AMP signaling cascade in frog, rat, and human cardiac myocytes

β-adrenergic receptors (β-ARs) mediate the positive inotropic effects of catecholamines by cAMP-dependent phosphorylation of the L-type Ca(2+) channels (LTCCs), which provide Ca(2+) for the initiation and regulation of cell contraction. The overall effect of cAMP-modulating agents on cardiac calcium...

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Bibliographic Details
Published in:	The journal of physiological sciences Vol. 66; no. 4; pp. 327 - 336
Main Authors:	Treinys, Rimantas, Bogdelis, Andrius, Rimkutė, Lina, Jurevičius, Jonas, Skeberdis, Vytenis Arvydas
Format:	Journal Article
Language:	English
Published:	Japan 01-07-2016
Subjects:	Animals Calcium Channels, L-Type - metabolism Cyclic AMP - metabolism Cyclic AMP-Dependent Protein Kinases - metabolism Female Humans Male Myocardium - metabolism Myocytes, Cardiac - metabolism Patch-Clamp Techniques Phosphorylation Rana esculenta Rats Rats, Wistar Receptors, Adrenergic, beta - metabolism Signal Transduction - physiology Protein kinase A Adenylyl cyclase Phosphatase Cardiac myocytes L-type Ca2+ channels Phosphodiesterase
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