Adenovirus-related acute liver failure treated with intravenous immunoglobulin

• Published in: Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993) Vol. 71; no. 2; p. 131
• Main Authors: Zavala-Rodríguez, Melisa, Martínez-Triana, Marco Antonio, Hernández-Morales, María Del Rocío, Peña-Vélez, Rubén
• Format: Journal Article
• Language: Spanish
• Published: Mexico 30-06-2024
• Subjects: Adenoviridae Infections - complications; Adenoviridae Infections - drug therapy; Adenovirus Infections, Human - complications; Adenovirus Infections, Human - drug therapy; Child, Preschool; Female; Humans; Immunoglobulins, Intravenous - therapeutic use; Liver Failure, Acute - etiology; Acute liver failure; Hepatitis; Immunoglobulin; Adenovirus
• DOI: 10.29262/ram.v71i2.1275
• EISSN: 2448-9190

Acute liver failure in pediatric age is a serious multisystem disease, characterized by a failure of the synthesis and detoxification function of the liver. Among the etiologies, viral infection should be investigated. Treatment is supportive and some cases require liver transplantation.
A 2-year-old girl was admitted for acute liver failure. The PCR viral panel was positive for Adenovirus 41 and IgG antibodies to SARS-CoV-2 were also found. Supportive treatment was started without improvement, so intravenous immunoglobulin was administered, with resolution of the liver failure.
Immunoglobulin has immunomodulatory mechanisms in children with severe acute hepatitis of infectious etiology, so in some cases, its administration can be considered as adjuvant therapy.