Behaviour of HIV/AIDS-related lymphoma in Pedro Kouri Institute. 2004-2005

• Published in: Revista cubana de medicina tropical Vol. 58; no. 3; pp. 248 - 253
• Main Authors: Miralles Alonso, Fernando, Ortega González, Lilia María, Oropesa González, Lisset, Francisco, Rodríguez Delgado, de Paz, Virginia Capó
• Format: Journal Article
• Language: Spanish
• Published: Cuba 01-09-2006
• Subjects: Academies and Institutes; Adult; Biomarkers, Tumor - blood; Blood Sedimentation; CD4 Lymphocyte Count; Cuba - epidemiology; Ethnic Groups - statistics & numerical data; Female; Humans; Immunocompromised Host; L-Lactate Dehydrogenase - blood; Lymphoma, AIDS-Related - blood; Lymphoma, AIDS-Related - epidemiology; Lymphoma, AIDS-Related - immunology; Lymphoma, AIDS-Related - pathology; Male; Neoplasm Staging; Prospective Studies; Risk Factors; Viral Load; Viremia - epidemiology; Young Adult; Cuba
• ISSN: 0375-0760

A prospective and descriptive study of 20 patients infected with HIV and admitted to "Pedro Kouri" Institute of Tropical Disease after a diagnosis of lymphoma was conducted. They were all evaluated at the onset of diagnosis by a thorough medical record exam and supportive studies such as complete blood count, globular sedimentation speed, CD4+ count, lactic acid dehydrogenase, HIV viral load, cytology and biopsy. Of this number, 85% presented with CD4+ count under 350 cell/mm3 at the time of diagnosis; however, only 55% showed viral loads exceeding 50,000 copies/mL. The predominant histological subtype was large diffuse cells and the most frequent location was the extrapulmonary site in 70% of cases. It called our attention that high levels of lactic acid dehydrogenase and extrapulmonary location of tumors were related. Statistically significant association was found (p < 0.05) between immunosuppresion condition of the patients given by CD4+ count below 350 cell/mm3 and advanced staging of the tumoral disease (stages III and IV).