Molecular biology of castration-resistant prostate cancer: basis for the novel therapeutic targets

Prostate cancer cells express the androgen receptor (AR) and need the presence of androgens to survive. Androgen suppression is the gold standard first-line therapy for metastatic disease. Almost all prostate cancer patients initially respond to hormonal therapy, but most of them gradually develop c...

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Bibliographic Details
Published in:	Archivos españoles de urología Vol. 66; no. 5; pp. 453 - 462
Main Authors:	Mellado, Begoña, Marin Aguilera, Mercedes, Pereira, Maria Veronica
Format:	Journal Article
Language:	English
Published:	Spain 01-06-2013
Subjects:	Androgen Antagonists - pharmacology Androgen Antagonists - therapeutic use Androgens - biosynthesis Animals Disease Progression Humans Male Molecular Biology Orchiectomy Prostatic Neoplasms - genetics Prostatic Neoplasms - metabolism Prostatic Neoplasms - surgery Receptors, Androgen - drug effects Receptors, Androgen - genetics Signal Transduction - physiology Tubulin - drug effects
Online Access:	Get full text
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