Choroidal metastasis as a presenting manifestation of a lung adenocarcinoma with response to afatinib

• Published in: Archivos de la Sociedad Española de Oftalmología Vol. 91; no. 11; pp. 551 - 555
• Main Authors: Contreras-Díaz, M, Medina-Tapia, A, Martínez-Bernal, G, Rueda-Rueda, T, López-Herrero, F, Molina-Socola, F E, Sánchez-Vicente, J L
• Format: Journal Article
• Language: English; Spanish
• Published: Spain 01-11-2016
• Subjects: Adenocarcinoma - diagnosis; Adenocarcinoma - drug therapy; Adenocarcinoma - enzymology; Adenocarcinoma - secondary; Adenocarcinoma of Lung; Afatinib; Antineoplastic Agents - pharmacology; Antineoplastic Agents - therapeutic use; Carcinoma, Non-Small-Cell Lung - diagnosis; Carcinoma, Non-Small-Cell Lung - drug therapy; Carcinoma, Non-Small-Cell Lung - enzymology; Carcinoma, Non-Small-Cell Lung - secondary; Choroid Neoplasms - diagnosis; Choroid Neoplasms - drug therapy; Choroid Neoplasms - enzymology; Choroid Neoplasms - secondary; ErbB Receptors - antagonists & inhibitors; Humans; Lung Neoplasms - diagnosis; Lung Neoplasms - drug therapy; Lung Neoplasms - enzymology; Male; Middle Aged; Neoplasm Proteins - antagonists & inhibitors; Protein Kinase Inhibitors - pharmacology; Protein Kinase Inhibitors - therapeutic use; Quinazolines - pharmacology; Quinazolines - therapeutic use; Remission Induction; Signal Transduction - drug effects; EFGR mutation; Afatinib; Mutación EFGR; Tumores coroideos; Choroidal tumours; Adenocarcinoma de pulmón; Metástasis coroidea; Choroidal metastasis; Lung adenocarcinoma
• ISSN: 1989-7286
• DOI: 10.1016/j.oftal.2016.03.002

We present the case of a 55-year-old man with a non-small cell lung adenocarcinoma, who presented with choroidal metastasis. The patient showed a decrease in visual acuity. His evaluation revealed unilateral choroidal metastasis secondary to carcinoma of the lung. The patient received afatinib with complete regression of choroidal metastasis after one year follow-up.
Choroidal metastasis may be the initial sign of lung cancer. This case highlights the importance of a thorough systemic evaluation in patients with choroidal tumours. Afatinib was effective against choroidal metastasis of a lung adenocarcinoma with EFGR mutation.