Comparative Study Among CO 2 Laser, Intralesional Vitamin D3, and Combined Intralesional Vitamin D3 and CO 2 Laser in Treatment of Palmoplantar Warts

• Published in: Dermatologic surgery Vol. 49; no. 8; pp. 771 - 776
• Main Authors: El Sharkawy, Dina Ahmed, Nada, Hanan Rabea, Radman Al-Kubati, Sahar
• Format: Journal Article
• Language: English
• Published: United States 01-08-2023
• Subjects: Cholecalciferol - therapeutic use; Humans; Injections, Intralesional; Lasers; Treatment Outcome; Vitamin D; Vitamins - therapeutic use; Warts - diagnosis
• ISSN: 1524-4725
• DOI: 10.1097/DSS.0000000000003846

Many therapeutic modalities are used for palmoplantar warts; whether destructive, such as chemical cautery, electrocautery, cryocautery, surgical removal, and laser ablation, or immunotherapeutic, stimulating the immune system against the virus such as intralesional vitamin D3 injection.
To compare the efficacy of intralesional vitamin D injection combined with CO 2 laser to the efficacy of either modality alone.
Eighty age- and sex-matched patients with palmoplantar warts were divided into 4 groups: Group A received intralesional vitamin D3 injections, group B received ablative CO 2 laser, group C received CO 2 laser and intralesional vitamin D3 injection, and group D (control group) were injected intralesionally with normal saline. Assessment was performed clinically, photographically, and dermoscopically before and after treatment to evaluate the response, and then, another assessment was performed after 3 months to detect any recurrence.
Complete clearance was seen in 90% of cases in group C, in 80% in group A, and in 75% in group B with no statistically significant difference.
Intralesional vitamin D, CO 2 laser, and the combination show comparable efficacy and recurrence rates. Intralesional vitamin D maybe a better option for people with a relative contraindication to CO 2 laser.