Features of apoptosis in conditions of the exposure to organochlorine compounds and vanadium

The cell structures involved into the apoptotic mechanism is an ideal object for the study of toxic effects produced by low-molecular-weight compounds on the immune system. Organic chlorine compounds and heavy metals were tested for their effects in the in vitro system. The experiments show that org...

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Bibliographic Details
Published in:	Gigiena i sanitarija no. 3; p. 15
Main Authors:	Dolgikh, O V, Zaĭtseva, N V, Dianova, D G, Karakhorina, R A
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-05-2012
Subjects:	Apoptosis - drug effects Child Child, Preschool Environmental Illness - chemically induced Environmental Illness - epidemiology Environmental Illness - pathology Humans Hydrocarbons, Chlorinated - adverse effects Immune System - drug effects Incidence Russia - epidemiology Trace Elements - adverse effects Vanadium - adverse effects Russia
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Summary:	The cell structures involved into the apoptotic mechanism is an ideal object for the study of toxic effects produced by low-molecular-weight compounds on the immune system. Organic chlorine compounds and heavy metals were tested for their effects in the in vitro system. The experiments show that organic chlorine compounds inhibit apoptotic cell death. An assessment of their results has demonstrated that vanadium promotes activation-induced lymphocyte death. Thus, there are multidirectional immune responses upon exposure to organic chlorine compounds and heavy metals.
ISSN:	0016-9900