Hemodynamic disorders and myocrdial insufficiency after toxic doses of propranolol

Results of an experimental study of the toxic action of propranolol on the cardiovascular system are presented. It was shown that i/p injections of propranolol (2 mg/100 g) cause circulatory insufficiency, activate free radical oxidation, and induce cardiac dysfunction.

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Bibliographic Details
Published in:	Vestnik Rossiĭskoĭ akademii medits︠i︡nskih nauk no. 11; p. 20
Main Authors:	Iatsiniuk, B B, Dolgikh, V T, Sentsov, V G, Medvedeva, S Iu
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 2011
Subjects:	Adrenergic beta-Antagonists - administration & dosage Adrenergic beta-Antagonists - toxicity Animals Cardiovascular System - drug effects Central Venous Pressure - drug effects Drug Dosage Calculations Electrocardiography - drug effects Heart Rate - drug effects Injections, Intraperitoneal Monitoring, Physiologic - methods Oxidative Stress - drug effects Propranolol - administration & dosage Propranolol - toxicity Rats Toxicology - methods
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Description
Summary:	Results of an experimental study of the toxic action of propranolol on the cardiovascular system are presented. It was shown that i/p injections of propranolol (2 mg/100 g) cause circulatory insufficiency, activate free radical oxidation, and induce cardiac dysfunction.
ISSN:	0869-6047