Spread of carcinogenic and mutagenic effects in the population of Gornaia Shoria

Mutagenic and carcinogenic effects were studied in the population of Gornaya Shoria, Kemerovo Region. The carcinogenic effects were evaluated on the basis of the data given by the Kemerovo regional cancer registry over 1990-2008. The standardized cancer morbidity index in Gornaya Shoria (342 per 100...

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Published in:Gigiena i sanitarija no. 2; p. 35
Main Authors: Minina, V I, Druzhinin, V G, Golovina, T A, Larin, S A, Mun, S A, Akhmat'ianova, V R, Bakanova, M L, Glushkov, A N
Format: Journal Article
Language:Russian
Published: Russia (Federation) 01-03-2011
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Abstract Mutagenic and carcinogenic effects were studied in the population of Gornaya Shoria, Kemerovo Region. The carcinogenic effects were evaluated on the basis of the data given by the Kemerovo regional cancer registry over 1990-2008. The standardized cancer morbidity index in Gornaya Shoria (342 per 100,000 population) exceeded the average index in the Kemerovo Region (286 per 100,000) in the same period. The mutagenic effects were estimated on the basis of the monitoring data on the frequency and spectrum of chromosomal aberrations in the peripheral blood lymphocytes of the dwellers of Gornaya Shoria for the 1992-2009 period. The mean level of chromosomal aberrations (5.31%) in the residents of Gornaya Shoria was found to be greater than the regional background mutation rate (2.86%) (p < 0.001). The values of individual aberration types (chromatid and chromosomal breaks, as well as chromosome-type exchange aberrations) were significantly higher in the dwellers of Gornaya Shoria than those in the basic control group. The revealed high mutagenic load in the inhabitants of Tashtagol District, Kemerovo Region, allows this area to be assigned to high genetic risk ones.
AbstractList Mutagenic and carcinogenic effects were studied in the population of Gornaya Shoria, Kemerovo Region. The carcinogenic effects were evaluated on the basis of the data given by the Kemerovo regional cancer registry over 1990-2008. The standardized cancer morbidity index in Gornaya Shoria (342 per 100,000 population) exceeded the average index in the Kemerovo Region (286 per 100,000) in the same period. The mutagenic effects were estimated on the basis of the monitoring data on the frequency and spectrum of chromosomal aberrations in the peripheral blood lymphocytes of the dwellers of Gornaya Shoria for the 1992-2009 period. The mean level of chromosomal aberrations (5.31%) in the residents of Gornaya Shoria was found to be greater than the regional background mutation rate (2.86%) (p < 0.001). The values of individual aberration types (chromatid and chromosomal breaks, as well as chromosome-type exchange aberrations) were significantly higher in the dwellers of Gornaya Shoria than those in the basic control group. The revealed high mutagenic load in the inhabitants of Tashtagol District, Kemerovo Region, allows this area to be assigned to high genetic risk ones.
Author Druzhinin, V G
Golovina, T A
Akhmat'ianova, V R
Bakanova, M L
Minina, V I
Glushkov, A N
Larin, S A
Mun, S A
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/21598642$$D View this record in MEDLINE/PubMed
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Snippet Mutagenic and carcinogenic effects were studied in the population of Gornaya Shoria, Kemerovo Region. The carcinogenic effects were evaluated on the basis of...
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StartPage 35
SubjectTerms Adolescent
Air Pollutants, Radioactive - adverse effects
Carcinogens, Environmental - adverse effects
Child
Environmental Illness - epidemiology
Female
Humans
Male
Mutagens - adverse effects
Radon - adverse effects
Retrospective Studies
Risk Assessment
Siberia - epidemiology
Title Spread of carcinogenic and mutagenic effects in the population of Gornaia Shoria
URI https://www.ncbi.nlm.nih.gov/pubmed/21598642
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