An experimental substantiation of nitric-oxide containing gas flow in the treatment of eye traumas

• Published in: Vestnik Rossiĭskoĭ akademii medits︠i︡nskih nauk no. 5; p. 40
• Main Authors: Chesnokova, N B, Gundorova, R A, Kvasha, O I, Bakov, V P, Davydova, N G, Beznos, O V, Stoliarova, E P, Kasakian, S M, Gorbacheva, O A, Shekhter, A B, Pekshev, A V
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 2003
• Subjects: alpha-Macroglobulins - metabolism; Animals; Cornea - metabolism; Corneal Injuries; Eye Injuries - drug therapy; Nitric Oxide - pharmacokinetics; Nitric Oxide - therapeutic use; Rabbits
• ISSN: 0869-6047

The hypothesis on the biostimulating effect of exogenous nitric oxide (NO) was made use of to develop a new method to stimulate the healing of wounds through treating them by a NO saturated gas flow. The above gas flow is generated by air-plasma unit "Plazon". The experimental and clinical studies confirmed that the NO-therapy is a highly effective treatment method for different lesions of the skin and soft tissues. We tried to use the above method in ophthalmology. A comprehensive experimental study was carried out to assess the impact of the NO-containing gas flow on the eyeball structures. An optimal mode was designed, which does not exert any influence on the intraocular pressure, Ph of the lachrymal fluid, antioxidative activity and on the proteinase-inhibitor balance in tears; no morphological changes occurred in the ocular tissue structures. The mentioned morphological and biochemical studies confirmed that the application of the NO-containing gas flow speeds up the healing, process of both an experimental cornea erosion and penetrating corneal wounds. Optimal modes of NO-therapy were defined for both types of lesions.