Development of glucose intolerance in male transgenic mice overexpressing human glycogen synthase kinase-3beta on a muscle-specific promoter

Glycogen synthase kinase-3 (GSK-3) protein levels and activity are elevated in skeletal muscle in type 2 diabetes, and inversely correlated with both glycogen synthase activity and insulin-stimulated glucose disposal. To explore this relationship, we have produced transgenic mice that overexpress hu...

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Bibliographic Details
Published in:	Metabolism, clinical and experimental Vol. 53; no. 10; pp. 1322 - 1330
Main Authors:	Pearce, Nigel J, Arch, Jonathan R S, Clapham, John C, Coghlan, Matthew P, Corcoran, Stacey L, Lister, Carolyn A, Llano, Andrea, Moore, Gary B, Murphy, Gregory J, Smith, Stephen A, Taylor, Colleen M, Yates, John W, Morrison, Alastair D, Harper, Alexander J, Roxbee-Cox, Lynne, Abuin, Alejandro, Wargent, Ed, Holder, Julie C
Format:	Journal Article
Language:	English
Published:	United States 01-10-2004
Subjects:	Animals Blotting, Western Body Composition - physiology Body Weight - physiology DNA Primers DNA, Complementary - biosynthesis DNA, Complementary - genetics Female Glucose Intolerance - genetics Glucose Tolerance Test Glycogen - metabolism Glycogen Synthase Kinase 3 - biosynthesis Glycogen Synthase Kinase 3 - genetics Glycogen Synthase Kinase 3 beta Humans Insulin Receptor Substrate Proteins Insulin Resistance - genetics Insulin Resistance - physiology Lipids - blood Liver - metabolism Male Mice Mice, Transgenic Muscle, Skeletal - metabolism Muscle, Skeletal - physiology Phenotype Phosphoproteins - biosynthesis Phosphoproteins - genetics Promoter Regions, Genetic - physiology Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - biosynthesis RNA, Messenger - genetics
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