Sudden death in organophosphoric poisoning--an unaccountable pathophysiologic mechanism?

• Published in: Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi Vol. 108; no. 2; p. 325
• Main Authors: Petriş, O, Gradinariu, Felicia, Totolin, M, Hurjui, J, Frasin, M, Lionte, Cătălina, Bologa, Cristina
• Format: Journal Article
• Language: Romanian, Moldovan
• Published: Romania 01-04-2004
• Subjects: Animals; Chromatography, Gas; Death, Sudden, Cardiac - etiology; Heart Diseases - chemically induced; Heart Diseases - metabolism; Insecticides - pharmacology; Insecticides - toxicity; Male; Models, Animal; Myocardium - metabolism; Rats; Rats, Wistar; Time Factors; Trichlorfon - pharmacokinetics; Trichlorfon - toxicity
• ISSN: 0048-7848

Sudden death related in literature to appear in IV-th - VIII-th day from organophosphoric intoxication does not have an unanimous accepted physiopathologic explanation.
Pharmacodynamic study of myocardial trichlorfon level in acute experiment.
Gas chromatographic determination of myocardial trichlorfon quantity in an experiment on white, male Wistar rats, daily sacrificed for the heart, until the tenth day from an digestive administration of a dose of 200mg/kg trichlorfon. RESULTS (mcg/g myocardial tissue): I day = 8, II day = 13.63, III day = 15, IV day = 18.96, V day = 19.6, VI day = 20.83, VII day = 21.21, VIII day = 21.33, IX day = 19.69, X day = 19.41.
An organophosphoric direct toxic mechanism is suggested, through accumulation over time of a certain level of myocardial concentration.