ERalpha as ligand-independent activator of CDH-1 regulates determination and maintenance of epithelial morphology in breast cancer cells

Estrogen receptor alpha (ERalpha) and E-cadherin are primary markers of luminal epithelial breast cancer cells with E-cadherin being a main caretaker of the epithelial phenotype. E-cadherin repression is needed for cancer cells to acquire motile and invasive properties, and it is known that in ER-po...

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Bibliographic Details

Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 106; no. 18; pp. 7420 - 7425
Main Authors:	Cardamone, Maria Dafne, Bardella, Chiara, Gutierrez, Arantxa, Di Croce, Luciano, Rosenfeld, Michael G, Di Renzo, Maria Flavia, De Bortoli, Michele
Format:	Journal Article
Language:	English
Published:	United States 05-05-2009
Subjects:	Amino Acid Sequence Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Cadherins - genetics Cell Line, Tumor Epithelial Cells - metabolism Epithelial Cells - pathology Estrogen Receptor alpha - metabolism Gene Expression Regulation, Neoplastic Humans Ligands Molecular Sequence Data Promoter Regions, Genetic Transcription, Genetic
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