Blockade of NF-kappaB improves cardiac function and survival without affecting inflammation in TNF-alpha-induced cardiomyopathy

NF-kappaB, a key transcription factor that regulates inflammatory processes, has been shown to be activated in the failing human heart with enhanced expression of proinflammatory cytokines. In the present study, we assessed the hypothesis that cardiotoxic effects of proinflammatory cytokines are med...

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Bibliographic Details
Published in:	Cardiovascular research Vol. 66; no. 3; pp. 520 - 529
Main Authors:	Kawamura, Natsumi, Kubota, Toru, Kawano, Shunichi, Monden, Yoshiya, Feldman, Arthur M, Tsutsui, Hiroyuki, Takeshita, Akira, Sunagawa, Kenji
Format:	Journal Article
Language:	English
Published:	England 01-06-2005
Subjects:	Animals Cardiomyopathies - immunology Cardiomyopathies - metabolism Cardiomyopathies - physiopathology CD4-Positive T-Lymphocytes - immunology Electrophoretic Mobility Shift Assay Genetic Engineering Macrophages - immunology Male Matrix Metalloproteinase 9 - analysis Matrix Metalloproteinase 9 - metabolism Mice Mice, Knockout Mice, Transgenic Myocardium - immunology Myocardium - metabolism NF-kappa B - genetics NF-kappa B - metabolism Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - metabolism Ventricular Remodeling
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