A TM2 residue in the beta1 subunit determines spontaneous opening of homomeric and heteromeric gamma-aminobutyric acid-gated ion channels

Gamma-aminobutyric acid type A (GABAA) receptors are major inhibitory neurotransmitter-gated ion channels in the central nervous system. GABAA receptors consist of multiple subunits and exhibit distinct pharmacological and channel properties. Of all GABAA receptor subunits, the beta subunit is thoug...

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Bibliographic Details

Published in:	The Journal of biological chemistry Vol. 279; no. 22; p. 22833
Main Authors:	Miko, Angela, Werby, Elena, Sun, Hui, Healey, Julia, Zhang, Li
Format:	Journal Article
Language:	English
Published:	United States 28-05-2004
Subjects:	Animals Ion Channel Gating - genetics Mutagenesis, Site-Directed Point Mutation Protein Subunits - metabolism Rats Receptors, GABA-A - analysis Receptors, GABA-A - chemistry Receptors, GABA-A - genetics Receptors, GABA-A - metabolism Recombinant Fusion Proteins - chemistry Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Structure-Activity Relationship Xenopus
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