A case report of skeletal muscle metastasis of renal cell carcinoma effectively treated with interferon-alpha

• Published in: Hinyokika kiyo. Acta urologica Japonica Vol. 46; no. 5; pp. 327 - 330
• Main Authors: Kaneko, T, Nozawa, T, Owari, Y, Unoura, A, Tamura, T, Kajikawa, T, Tamada, H, Ujiie, T, Okamoto, T, Takata, K, Sakuma, T
• Format: Journal Article
• Language: Japanese
• Published: Japan 01-05-2000
• Subjects: Aged; Antineoplastic Agents - administration & dosage; Carcinoma, Renal Cell - drug therapy; Carcinoma, Renal Cell - secondary; Carcinoma, Renal Cell - surgery; Female; Humans; Injections, Intramuscular; Interferon-alpha - administration & dosage; Kidney Neoplasms - pathology; Kidney Neoplasms - surgery; Muscle Neoplasms - drug therapy; Muscle Neoplasms - secondary; Muscle, Skeletal; Nephrectomy; Ribs
• ISSN: 0018-1994

The skeletal muscle is a very rare site of metastasis in renal cell carcinoma. We report the third case of skeletal muscle metastasis of renal cell carcinoma effectively treated with interferon-alpha. The patient was a 74-year-old woman who had undergone radical nephrectomy on the left side for renal cell carcinoma on April 23, 1990, and had been observed as an outpatient. In June 1997, she was admitted with a diagnosis of metastasis in the left great adductor muscle and right sixth rib, as well as multiple lung metastasis. The metastatic lesion in the great adductor muscle decreased in size by more than 50% following concomitant intramuscular administration of natural interferon-alpha (nIFN-alpha). In the other metastatic lesions, nIFN-alpha-sensitive and resistant metastatic foci were intermingled. Thus, the primary focus in the present study was presumably composed of several clones with different sensitivities to nIFN-alpha.