Analysis of TCRalphabeta combinations used by simian immunodeficiency virus-specific CD8+ T cells in rhesus monkeys: implications for CTL immunodominance

Immunodominance is a common feature of Ag-specific CTL responses to infection or vaccines. Understanding the basis of immunodominance is crucial to understanding cellular immunity and viral evasion mechanisms and will provide a rational approach for improving HIV vaccine design. This study was perfo...

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Bibliographic Details

Published in:	The Journal of immunology (1950) Vol. 178; no. 6; pp. 3409 - 3417
Main Authors:	Hasegawa, Atsuhiko, Moriya, Chikaya, Liu, Huining, Charini, William A, Vinet, Heather C, Subbramanian, Ramu A, Sen, Pritha, Letvin, Norman L, Kuroda, Marcelo J
Format:	Journal Article
Language:	English
Published:	United States 15-03-2007
Subjects:	Animals Antigens, Viral - immunology CD8-Positive T-Lymphocytes - immunology Gene Products, gag - immunology Gene Products, pol - immunology Gene Rearrangement, alpha-Chain T-Cell Antigen Receptor - immunology Gene Rearrangement, beta-Chain T-Cell Antigen Receptor - immunology Histocompatibility Antigens Class I - immunology Immunodominant Epitopes - immunology Macaca mulatta Peptides - immunology Receptors, Antigen, T-Cell, alpha-beta - immunology SAIDS Vaccines - immunology Simian Immunodeficiency Virus - immunology
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