Salmonella enterica serovar Enteritidis dam mutant induces low NOS-2 and COX-2 expression in macrophages via attenuation of MAPK and NF-kappaB pathways

Although dam mutants of Salmonella have been proposed as live vaccines, their capacity to trigger cell inflammatory cascades has not been fully elucidated. We investigated in detail the ability of Salmonella enterica dam mutant to activate the signalling pathways of the inflammatory response in RAW...

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Bibliographic Details

Published in:	Microbes and infection Vol. 10; no. 14-15; pp. 1431 - 1439
Main Authors:	Cristina Cerquetti, M, Hovsepian, Eugenia, Sarnacki, Sebastian H, Goren, Nora B
Format:	Journal Article
Language:	English
Published:	France 01-11-2008
Subjects:	Animals Bacterial Proteins - genetics Cell Line Cyclooxygenase 2 - biosynthesis Dinoprostone - metabolism Macrophages - immunology Mice Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors NF-kappa B - antagonists & inhibitors Nitric Oxide - metabolism Nitric Oxide Synthase Type II - biosynthesis Salmonella enteritidis - genetics Salmonella enteritidis - immunology Site-Specific DNA-Methyltransferase (Adenine-Specific) - deficiency
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