Role of activated CaMKII in abnormal calcium homeostasis and I(Na) remodeling after myocardial infarction: insights from mathematical modeling

Ca(2+)/calmodulin-dependent protein kinase II is a multifunctional serine/threonine kinase with diverse cardiac roles including regulation of excitation contraction, transcription, and apoptosis. Dynamic regulation of CaMKII activity occurs in cardiac disease and is linked to specific disease phenot...

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Bibliographic Details
Published in:	Journal of molecular and cellular cardiology Vol. 45; no. 3; pp. 420 - 428
Main Authors:	Hund, Thomas J, Decker, Keith F, Kanter, Evelyn, Mohler, Peter J, Boyden, Penelope A, Schuessler, Richard B, Yamada, Kathryn A, Rudy, Yoram
Format:	Journal Article
Language:	English
Published:	England 01-09-2008
Subjects:	Animals Calcium - metabolism Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism Calcium-Calmodulin-Dependent Protein Kinase Type 2 - physiology Disease Models, Animal Dogs Enzyme Activation - physiology Homeostasis - physiology Intracellular Fluid - enzymology Intracellular Fluid - metabolism Models, Cardiovascular Myocardial Infarction - metabolism Myocardial Infarction - pathology Pericardium - cytology Pericardium - enzymology Pericardium - pathology Phosphorylation Rabbits Sodium - metabolism
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