Endothelin-1 is a potent stimulator of alpha1beta1 integrin-mediated collagen matrix remodeling by rat mesangial cells

Endothelin-1 (ET) is known to stimulate mesangial cell (MC) proliferation, extracellular matrix (ECM) synthesis, and thereby contribute to the progression of glomerulonephritis (GN). To clarify the molecular and cellular mechanisms of how ET is involved in the development of glomerular sclerosis, we...

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Bibliographic Details
Published in:	Biochemical and biophysical research communications Vol. 299; no. 4; pp. 555 - 561
Main Authors:	Kitamura, A, Kagami, S, Urushihara, M, Kondo, S, Yoshizumi, M, Tamaki, T, Kuroda, Y
Format:	Journal Article
Language:	English
Published:	United States 13-12-2002
Subjects:	Animals Cell Adhesion - physiology Cell Movement - physiology Cells, Cultured Collagen - metabolism Dose-Response Relationship, Drug Endothelin-1 - metabolism Endothelin-1 - pharmacology Gels - chemistry Glomerular Mesangium - cytology Glomerular Mesangium - drug effects Glomerular Mesangium - metabolism Integrin alpha1beta1 - metabolism Matrix Metalloproteinase 2 - metabolism Rats Rats, Sprague-Dawley
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