Differential expression patterns of Wnt and beta-catenin/TCF target genes in the uterus of immature female rats exposed to 17alpha-ethynyl estradiol

To characterize the effects of an estrogen receptor (ER) agonist on the gene expressions in the uterus, immature female rats were administered once orally with 17alpha-ethynyl estradiol (EE, 3 mug/kg), a potent ER agonist. We focused on four categories of sex steroid hormone receptor genes: well-kno...

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Bibliographic Details
Published in:	Toxicological sciences Vol. 91; no. 2; pp. 419 - 430
Main Authors:	Katayama, Seiichi, Ashizawa, Koji, Fukuhara, Tadahiro, Hiroyasu, Makoto, Tsuzuki, Yasuhiro, Tatemoto, Hideki, Nakada, Tadashi, Nagai, Kenji
Format:	Journal Article
Language:	English
Published:	United States 01-06-2006
Subjects:	Animals beta Catenin - genetics beta Catenin - metabolism Estrogens - pharmacology Ethinyl Estradiol - pharmacology Female Gene Expression Profiling Gene Expression Regulation - drug effects Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Rats Rats, Inbred Strains RNA, Messenger - metabolism TCF Transcription Factors - genetics TCF Transcription Factors - metabolism Uterus - drug effects Uterus - metabolism Wnt Proteins - genetics Wnt Proteins - metabolism Wnt-5a Protein Wnt4 Protein
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