Does nitroglycerin show the properties of a selective venodilator?

The central hemodynamic effect of continuous intravenous nitroglycerin infusion at an increasing rate (0.01-0.1 microg x kg(-1) x min(-1)) was evaluated by noninvasive (tetrapolar rheography) and invasive (pulmonary arterial catheterization) techniques. The study included 10 healthy volunteers and 3...

Full description

Saved in:

Bibliographic Details
Published in:	Anesteziologiia i reanimatologiia no. 5; p. 51
Main Authors:	Lebedinskiĭ, K M, Puzanova, I V, Parvanian, S G, Kurapeev, I S
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-09-2007
Subjects:	Adult Aged Cardiography, Impedance Humans Infusions, Intravenous Middle Aged Myocardial Ischemia - drug therapy Myocardial Ischemia - physiopathology Myocardial Ischemia - surgery Myocardial Revascularization Nitroglycerin - administration & dosage Nitroglycerin - pharmacology Nitroglycerin - therapeutic use Vasodilation - drug effects Vasodilator Agents - administration & dosage Vasodilator Agents - pharmacology Vasodilator Agents - therapeutic use
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	The central hemodynamic effect of continuous intravenous nitroglycerin infusion at an increasing rate (0.01-0.1 microg x kg(-1) x min(-1)) was evaluated by noninvasive (tetrapolar rheography) and invasive (pulmonary arterial catheterization) techniques. The study included 10 healthy volunteers and 30 patients having usual indications for nitroglycerin infusion. The findings suggest that when even infused at low rates, nitroglycerin canses mainly arteriolar vasodilatation, which appears as increased stroke volume due to the predominance of diminished postload over lowered preload. It is obvious that the notion of nitroglycerin as a selective venodilator should be revised.
ISSN:	0201-7563