Inhibitory effect of foscarnet and acyclovir on reproduction of human herpesvirus 6 in cell culture

Two practically important antiviral agents, i.e. foscarnet (phosphonoformic acid, foscavir) and acyclovir, and their inhibitory effect on reproduction of human herpesvirus 6 (HHV-6) were investigated in an experiment with sensitive lymphoblastoic cell line HSB-2. Phosphonoformic acid (PFA) was shown...

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Bibliographic Details
Published in:	Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] Vol. 54; no. 1-2; p. 17
Main Authors:	Mel'nichenko, A V, L'vov, N D, Galegov, G A
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 2009
Subjects:	Acyclovir - pharmacology Antiviral Agents - pharmacology Cell Line, Tumor Cell Survival - drug effects Cytopathogenic Effect, Viral Dose-Response Relationship, Drug Foscarnet - pharmacology Herpesvirus 6, Human - drug effects Herpesvirus 6, Human - physiology Humans Virus Replication - drug effects
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Summary:	Two practically important antiviral agents, i.e. foscarnet (phosphonoformic acid, foscavir) and acyclovir, and their inhibitory effect on reproduction of human herpesvirus 6 (HHV-6) were investigated in an experiment with sensitive lymphoblastoic cell line HSB-2. Phosphonoformic acid (PFA) was shown advantageous vs. acyclovir. In a model of HHV-6 infection acyclovir was low active (chemotherapeutic index of 0.9) and its use in clinical practice is not useful, whereas PFA (chemoterapeutic index of 10) and similar agents showed significant antiviral activity that indicated the necessity of their further investigation.
ISSN:	0235-2990