Effect of arecholine and atropine administration on the carboxypeptidase H and phenylmethylsulfonyl fluoride-inhibited carboxypeptidase activities in the rat nervous tissue

The effect of a single dose administration of arecholine and atropine on the activities of carboxypeptidase H and phenylmethylsulfonyl fluoride-inhibited carboxypeptidase involved into the final stage of formation of biologically active neuropeptides from precursors has been studied. Changes in the...

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Bibliographic Details
Published in:	Biomeditsinskaia khimiia Vol. 54; no. 2; p. 201
Main Authors:	Solov'ev, V B, Gengin, M T
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-03-2008
Subjects:	Adrenal Glands - drug effects Adrenal Glands - enzymology Animals Arecoline - pharmacology Atropine - pharmacology Brain - drug effects Brain - enzymology Carboxypeptidase H - metabolism Carboxypeptidases - metabolism Cholinergic Agents - pharmacology Cholinergic Agonists - pharmacology Cholinergic Antagonists - pharmacology Male Organ Specificity Phenylmethylsulfonyl Fluoride - pharmacology Rats
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Summary:	The effect of a single dose administration of arecholine and atropine on the activities of carboxypeptidase H and phenylmethylsulfonyl fluoride-inhibited carboxypeptidase involved into the final stage of formation of biologically active neuropeptides from precursors has been studied. Changes in the enzyme activities were evident during at least 72 h after administration of these drugs. These results suggest that one of possible mechanisms of reduction of neuropeptide levels by arecholine and atropine consists in suppression of activity of enzymes taking part in there metabolism--carboxypeptidase H and phenylmethylsulfonyl fluoride-inhibited carboxypeptidase.
ISSN:	2310-6972