Anti-CD4 autoimmunity in HIV-infected persons in Russia

The frequency of anti-CD4 antibodies was determined in the sera or plasma derived from the patients infected with HIV-1 belonging to different genetic subgroups. The anti-CD4-antibodies in a dilution of > or = 1:1000 were found in 14% of the patients infected with the gagA/envA virus characterist...

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Bibliographic Details
Published in:	Voprosy virusologiĭ Vol. 50; no. 5; p. 15
Main Authors:	Lideman, L F, Kasennova, E V, Denisova, G F, Stakhanova, V M, Zverev, S Ia, Gibadulin, R A, Bobkov, A F
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-09-2005
Subjects:	Amino Acid Sequence Autoantibodies - blood CD4 Antigens - immunology Consensus Sequence Epitopes, T-Lymphocyte Female Gene Products, nef - genetics HIV Infections - blood HIV Infections - virology HIV-1 - genetics Human Immunodeficiency Virus Proteins Humans Male Molecular Sequence Data nef Gene Products, Human Immunodeficiency Virus Species Specificity Substance Abuse, Intravenous - blood Viral Regulatory and Accessory Proteins - genetics
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Summary:	The frequency of anti-CD4 antibodies was determined in the sera or plasma derived from the patients infected with HIV-1 belonging to different genetic subgroups. The anti-CD4-antibodies in a dilution of > or = 1:1000 were found in 14% of the patients infected with the gagA/envA virus characteristic for injectable drug users in East Europe. The frequency of autoimmune antibodies among the HIV-infected patients with envB virus was substantially less (4.4%). Competitive ELISA using monoclonal antibodies to different CD4 domains demonstrated that irrespective of the viral genotype, the autoimmune epitope is located within the D4 or D3/D4 domains of CD4 receptor.
ISSN:	0507-4088