Evaluation of nasal inflammation

• Published in: Anales otorrinolaringologicos ibero-americanos Vol. 33; no. 2; p. 123
• Main Authors: De La Torre Morín, F, Sánchez Machín, I
• Format: Journal Article
• Language: Spanish
• Published: Spain 2006
• Subjects: Cytokines - metabolism; Eosinophils - metabolism; Humans; Inflammation - metabolism; Inflammation - pathology; Mast Cells - pathology; Nasal Cavity - metabolism; Nasal Cavity - pathology; Phospholipids - metabolism; Receptors, Histamine H2 - metabolism
• ISSN: 0303-8874

In the reaction of immediate hypersensibility to alergene is joined to its specific type IgE antibody, also united to the high affinity receptors for IgE (FccI) of the effecters cells fundamentally mastocites and basophiles. The interbreeding of these molecules Fcc to RI, after the union ofpolyvalent antigenes to IgE, active these cells, producing three biologic responses: excitosis of the preformed content of its granules, synthesization of lipidic mediators and citoquine secretion. The inflammation mediators are in last term, substances responsible of the clinic symptomatology. They can be divided generally in preformed mediators (biogene amines and macromolecules of the granules) and of new synthese mediators (lipidic and citoquine mediators).