Agonist-, antagonist-, and benzodiazepine-induced structural changes in the alpha1 Met113-Leu132 region of the GABAA receptor

The structural basis by which agonists, antagonists, and allosteric modulators exert their distinct actions on ligand-gated ion channels is poorly understood. We used the substituted cysteine accessibility method to probe the structure of the GABAA receptor in the presence of ligands that elicit dif...

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Bibliographic Details

Published in:	Molecular pharmacology Vol. 71; no. 2; p. 483
Main Authors:	Kloda, Jessica Holden, Czajkowski, Cynthia
Format:	Journal Article
Language:	English
Published:	United States 01-02-2007
Subjects:	Amino Acid Sequence Animals Benzodiazepines - pharmacology Binding Sites - genetics Cysteine - genetics Electrophysiology Flurazepam - pharmacology GABA Modulators - pharmacology GABA-A Receptor Agonists GABA-A Receptor Antagonists Ion Channel Gating Mutagenesis, Site-Directed Oocytes Protein Conformation - drug effects Xenopus laevis
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