The use of flavonoid antioxidants in the complex treatment of patients with peripheral vitreo-chorioretinal dystrophies and dystrophic retinal detachment

• Published in: Vestnik oftal'mologii Vol. 120; no. 4; p. 14
• Main Authors: Karazhaeva, M I, Saksonova, E O, Klebanov, G I, Liubitskiĭ, O B, Gur'eva, N V
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 01-07-2004
• Subjects: Administration, Oral; Adolescent; Adult; Aged; Antioxidants - administration & dosage; Antioxidants - therapeutic use; Choroid Diseases - drug therapy; Choroid Diseases - metabolism; Flavonoids - administration & dosage; Flavonoids - therapeutic use; Follow-Up Studies; Ginkgo biloba; Humans; Lipid Peroxidation; Middle Aged; Phytotherapy; Quercetin; Retinal Degeneration - drug therapy; Retinal Degeneration - metabolism; Retinal Detachment - drug therapy; Retinal Detachment - metabolism; Retinal Detachment - surgery; Time Factors; Vitreous Body
• ISSN: 0042-465X

Parameters of lipid peroxidation (LP) and antioxidant activity (AOA) of tear and blood plasma were examined in 22 healthy subjects (44 eyes) as well as in 33 patients with peripheral vitreochoreoretinal dystrophies (PVCRD--60 eyes), in 32 patients with non-operated dystrophic retinal detachment (DRD--34 eyes) and in 135 patients with operated retinal detachment, stable visual functions and with the postoperative period ranging from 4 months to 10 years (137 eyes). The results denoted a lower tear AOA (on the average by 35%) in patients with DRD and PVCRD, whereas, the blood plasma AOA or LP products' content remained unchanged. It is indicative of a local nature of metabolic impairments, specifically, of impairments in the system of antioxidant protection of the eye. Flavonoid antioxidants (dikvertin and ginkgo biloba) reduced the content of LP products, and induced the AOA in tear and blood plasma in patients with PVCRD and retinal detachment; they also improved the visual functions in patients with operated retinal detachment. Therefore, the flavonoid antioxidants can be recommended for adding to the complex treatment of PVCRD and DRD for the purpose of improving and stabilizing the visual functions and for neuroprotection.