Synthesis of the lupane group triterpenoids and there hepatoprotective activity

Hemisuccinates, hemiphthalates, acetylsalicylates, cinnamates, and p-methoxycinnamates of lupeol, betulin, and 3-O-acetylbetulin were synthesized via interaction with corresponding acid anhydrides or acid chlorides. A number of betulin esters in position 3 and 28 were shown to exhibit a pronounced h...

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Bibliographic Details
Published in:	Bioorganicheskaia khimiia Vol. 26; no. 3; p. 215
Main Authors:	Flekhter, O B, Karachurina, L T, Poroĭkov, V V, Nigmatullina, L R, Baltina, L A, Zarudiĭ, F S, Davydova, V A, Spirikhin, L V, Baĭkova, I P, Galin, F Z, Tolstikov, G A
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-03-2000
Subjects:	Animals Anti-Inflammatory Agents - chemical synthesis Anti-Inflammatory Agents - chemistry Anti-Inflammatory Agents - pharmacology Liver - drug effects Liver - pathology Pentacyclic Triterpenes Rats Triterpenes - chemical synthesis Triterpenes - chemistry Triterpenes - pharmacology
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Summary:	Hemisuccinates, hemiphthalates, acetylsalicylates, cinnamates, and p-methoxycinnamates of lupeol, betulin, and 3-O-acetylbetulin were synthesized via interaction with corresponding acid anhydrides or acid chlorides. A number of betulin esters in position 3 and 28 were shown to exhibit a pronounced hepatoprotective effect similar to that of betulin and silibor. These experimental data were in a good agreement with the computer prediction of their biological activity. Betulin 3,28-bis-hemiphthalate was more effective than carsil in models of experimental hepatitis caused by carbon tetrachloride, tetracycline, and ethanol.
ISSN:	0132-3423