Anphen and energy status of the animal body

Energy status of rats was altered after administration of anphen [2,4-(hydroxy-3,5-ditretbutyl phenyl)-2-aminomalonic acid] at a dose of 40 mg/kg. Within 30 min after administration, maximal rates of NAD-dependent substrates and succinate oxidation were detected in liver mitochondria, which appears...

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Bibliographic Details
Published in:	Voprosy meditsinskoi khimii Vol. 39; no. 6; p. 6
Main Authors:	Zhigacheva, I V, Vlasova, M E, Kaplan, E Ia, Pakhomov, V Iu
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-11-1993
Subjects:	Animals Antioxidants - pharmacology Electron Spin Resonance Spectroscopy Electron Transport Energy Metabolism Glycerolphosphate Dehydrogenase - metabolism Lipid Peroxidation Lymphocytes - enzymology Male Malonates - pharmacology Mitochondria, Liver - drug effects Mitochondria, Liver - metabolism Rats Succinate Dehydrogenase - metabolism
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Summary:	Energy status of rats was altered after administration of anphen [2,4-(hydroxy-3,5-ditretbutyl phenyl)-2-aminomalonic acid] at a dose of 40 mg/kg. Within 30 min after administration, maximal rates of NAD-dependent substrates and succinate oxidation were detected in liver mitochondria, which appears to occur due to activation of the mitochondrogenesis. The rate of electron transport in respiratory chain of mitochondria was decreased 1.3-1.6-fold within 1-1.5 hr, whereas within 3 hrs the patterns of oxidation and energetic coupling in liver mitochondria were reduced to control values. The similar alterations were observed in activities of lymphocyte alpha-glycerophosphate- and succinate dehydrogenases. Shifts in the pool of lipid peroxidation products in biological membranes was apparently responsible for alterations in activity of the energy metabolizing enzymes in lymphocytes and liver mitochondria.
ISSN:	0042-8809