Atherogenic dyslipidemia in adolescents: its relation to ischemic heart disease in their fathers and the possibility of its prognosis

Comparison of a group of adolescents aged 11-16 years whose fathers had angiographically documented coronary atherosclerosis in youth with those matched by sex and age whose parents were clinically healthy yielded the following discriminant function (DF) involving lipid and apoprotein indices of the...

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Bibliographic Details
Published in:	Kardiologiia Vol. 29; no. 9; p. 28
Main Authors:	Mete'lskaia, V A, Aĭngorn, E D, Maslennikova, G Ia, Dorofeeva, T G, Gorchakova, N N, Sipiagina, A E, Ruzhanskaia, T V, Grigo'reva, I V, Olfe'rev, A M, Beloko'n, N A
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-09-1989
Subjects:	Adolescent Adult Child Coronary Artery Disease - blood Coronary Artery Disease - etiology Coronary Artery Disease - genetics Fathers Female Humans Hyperlipidemias - blood Hyperlipidemias - complications Lipids - blood Male Middle Aged Prognosis Risk Factors
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Summary:	Comparison of a group of adolescents aged 11-16 years whose fathers had angiographically documented coronary atherosclerosis in youth with those matched by sex and age whose parents were clinically healthy yielded the following discriminant function (DF) involving lipid and apoprotein indices of the plasma lipid system: DF = [apo B] X 0.03-[HDL cholesterol] X 0.04-0.81. DF greater than or equal to 0 discriminates from the controls 32% of the offsprings from the fathers with a history, DF less than 0 correctly classifies 98% of adolescents from the controls. The adolescents who have DF greater than or equal to 0 amounted to about 19% in representative samples of Moscow adolescents. Moreover, DF with 80% probability makes it possible to predict the time course of serum lipid levels in adolescents within 2 years.
ISSN:	0022-9040