Principle of plotting the age distribution of persons with hereditary diseases at various ages of onset and differential mortality

A method for ascertaining the mode of current age distributions is suggested for accurate quantitative assessment of some genetic parameters of hereditary diseases, such as age-specific penetrance, frequency of heterozygotes in the general population, fitness. The method is based on estimating the a...

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Bibliographic Details
Published in:	Genetika Vol. 21; no. 8; p. 1403
Main Authors:	Bazhenova, M D, Al'tshuler, B A, Tatishvili, G G
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-08-1985
Subjects:	Age Factors Epidemiologic Methods Genetic Carrier Screening - methods Genetic Diseases, Inborn - genetics Genetic Diseases, Inborn - mortality Genetics, Population Humans
Online Access:	Get more information
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Summary:	A method for ascertaining the mode of current age distributions is suggested for accurate quantitative assessment of some genetic parameters of hereditary diseases, such as age-specific penetrance, frequency of heterozygotes in the general population, fitness. The method is based on estimating the age-specific proportion of affected among the total number of heterozygotes, which seems more reasonable than the common methodology, considering the age-specific proportion of affected among all cases of the disease indicated.
ISSN:	0016-6758