The effect of the level of lipid peroxidation and the pH value of a liposomal suspension on its antibacterial activity

Multilamellar phosphatidylcholine liposomes have been shown to possess antibacterial activity with respect to Pseudomonas aeruginosa and Staphylococcus aureus. An increase in the level of lipid peroxidation products in liposomal suspension as the consequence of the earlier oxidation of liposomal lip...

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Bibliographic Details
Published in:	Žurnal mikrobiologii, ėpidemiologii i immunobiologii no. 1; p. 6
Main Authors:	Mel'iantseva, L P, Kreĭnes, V M, Bulgakov, V G
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-01-1995
Subjects:	Drug Carriers Hydrogen-Ion Concentration Lipid Peroxidation - immunology Liposomes - immunology Pseudomonas aeruginosa - drug effects Pseudomonas aeruginosa - growth & development Staphylococcus aureus - drug effects Staphylococcus aureus - growth & development Suspensions Time Factors
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Summary:	Multilamellar phosphatidylcholine liposomes have been shown to possess antibacterial activity with respect to Pseudomonas aeruginosa and Staphylococcus aureus. An increase in the level of lipid peroxidation products in liposomal suspension as the consequence of the earlier oxidation of liposomal lipid leads to a considerable increase in the antibacterial activity of liposomes. The pH of the liposomal suspension has also an essential influence on its activity. If the pH of the suspension has acidic values, its antibacterial activity increases. The bactericidal action of liposomal suspension is more pronounced with respect to S. aureus, than to P. aeruginosa.
ISSN:	0372-9311