Desensitization with acetylsalicylate and salicylate of fructose-1,6-diphosphatase from the rabbit liver and skeletal muscles to allosteric inhibition of AMP

Acetylsalicylate and salicylate partially desensitized fructose 1,6-biphosphatase from rabbit liver and skeletal muscle to allosteric AMP inhibition. The desensitization was accompanied by a decrease in cooperativity between allosteric sites especially distinct for the liver isoenzyme. The effect of...

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Bibliographic Details
Published in:	Voprosy meditsinskoi khimii Vol. 32; no. 2; p. 50
Main Authors:	Beliaeva, N F, Glinka, E Iu, Nikulin, I R, Kagan, Z S
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-03-1986
Subjects:	Adenosine Monophosphate - pharmacology Allosteric Regulation Animals Aspirin - pharmacology Fructose-Bisphosphatase - antagonists & inhibitors In Vitro Techniques Kinetics Liver - enzymology Muscles - enzymology Rabbits Salicylates - pharmacology
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Summary:	Acetylsalicylate and salicylate partially desensitized fructose 1,6-biphosphatase from rabbit liver and skeletal muscle to allosteric AMP inhibition. The desensitization was accompanied by a decrease in cooperativity between allosteric sites especially distinct for the liver isoenzyme. The effect of salicylate on both isoenzymes was more pronounced than that of acetylsalicylate. No essential differences in the effect of the compounds studied on these isoenzymes were found.
ISSN:	0042-8809