Effects of a morphine-clomipramine combination on a test of experimental analgesia

Morphine (2.5 mg/kg sc) i.e. at a non-antinociceptive dose, augmented clomipramine-induced antinociceptive effect but failed to alter the values of clomipramine (10, 20, 40 mg/kg orally) levels in rats. These results suggest that the potentiation of clomipramine-induced analgesia by morphine does no...

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Bibliographic Details
Published in:	Revue neurologique Vol. 141; no. 10; p. 669
Main Authors:	Montastruc, J L, Tran, M A, Guiol, C, Blanc, M, Gaillard, G, Cotonat, J, Montastruc, P
Format:	Journal Article
Language:	French
Published:	France 1985
Subjects:	Analgesics Animals Clomipramine - pharmacology Drug Synergism Drug Therapy, Combination Male Morphine - pharmacology Rats Rats, Inbred Strains Receptors, Opioid - metabolism
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Summary:	Morphine (2.5 mg/kg sc) i.e. at a non-antinociceptive dose, augmented clomipramine-induced antinociceptive effect but failed to alter the values of clomipramine (10, 20, 40 mg/kg orally) levels in rats. These results suggest that the potentiation of clomipramine-induced analgesia by morphine does not result from a peripheral pharmacokinetic mechanism but probably involves a central interaction between clomipramine and opiates pathways.
ISSN:	0035-3787