Xanthine lithiasis in a case of Lesch-Nyhan syndrome treated with allopurinol

Classically it is considered that vital prognosis of Lesch-Nyhan syndrome depends on renal affectation secondary to uric nephropathy. A case of Lesch-Nyhan syndrome treated with Allopurinol is described which presented multiple and bilateral renal stones by precipitation of xanthine. Treatment with...

Full description

Saved in:

Bibliographic Details
Published in:	Anales españoles de pediatría Vol. 19; no. 5; p. 401
Main Authors:	Loris Pablo, C, Oliván del Cacho, M J, Heras Gironella, M, Sierra Sirvant, J, Martínez Escribano, M P, Izaguirre Zugazaga, C, Lázaro Castillo, J, March, A
Format:	Journal Article
Language:	Spanish
Published:	Spain 01-11-1983
Subjects:	Allopurinol - adverse effects Allopurinol - therapeutic use Child Humans Kidney Calculi - etiology Lesch-Nyhan Syndrome - complications Lesch-Nyhan Syndrome - drug therapy Lesch-Nyhan Syndrome - metabolism Male Xanthines - metabolism
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Classically it is considered that vital prognosis of Lesch-Nyhan syndrome depends on renal affectation secondary to uric nephropathy. A case of Lesch-Nyhan syndrome treated with Allopurinol is described which presented multiple and bilateral renal stones by precipitation of xanthine. Treatment with Allopurinol inhibits the formation of uric acid and qualitatively renal excretion of oxypurines modifies. In special circumstances (disminution of urinary output and pH), they can precipitate and originate a radiotransparent lithiasis with uric lithiasis. Interest of this case, lies in being alert to possible xanthine stone formation in patients with a large excretion of purinics metabolites, who are treated with Allopurinol.
ISSN:	0302-4342