Study of the role of the endothelium in the development of coronary vessel reactions of different etiologies

• Published in: Kardiologiia Vol. 30; no. 1; p. 62
• Main Authors: Sagach, V F, Dmitrieva, A V
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 01-01-1990
• Subjects: Animals; Coronary Vasospasm - etiology; Coronary Vessels - physiopathology; Dogs; Endothelium, Vascular - physiopathology; Hypoxia - complications; Hypoxia - physiopathology; Muscle, Smooth, Vascular - physiopathology; Vascular Resistance - physiology; Vasoconstriction - physiology
• ISSN: 0022-9040

Experiments were made in dogs under the conditions of blood autoperfusion of one of the left coronary artery branches. Chemical removal of the endothelium with saponin was shown to lead to abnormal coronary reactivity, eliminate dilatory and give rise to constrictive responses to ATP, acetylcholine, histamine. After an initial coronary dilatation, hypoxic hypoxia resulted in a pronounced increase in coronary resistance and a reduction in coronary flow in intact animals. Preliminary deendothelization of the coronary artery caused disappearance of a dilatatory phase of the reaction, acceleration and enhancement of coronary constriction in response to hypoxia.