Study of the role of the endothelium in the development of coronary vessel reactions of different etiologies

Experiments were made in dogs under the conditions of blood autoperfusion of one of the left coronary artery branches. Chemical removal of the endothelium with saponin was shown to lead to abnormal coronary reactivity, eliminate dilatory and give rise to constrictive responses to ATP, acetylcholine,...

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Bibliographic Details
Published in:	Kardiologiia Vol. 30; no. 1; p. 62
Main Authors:	Sagach, V F, Dmitrieva, A V
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-01-1990
Subjects:	Animals Coronary Vasospasm - etiology Coronary Vessels - physiopathology Dogs Endothelium, Vascular - physiopathology Hypoxia - complications Hypoxia - physiopathology Muscle, Smooth, Vascular - physiopathology Vascular Resistance - physiology Vasoconstriction - physiology
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Summary:	Experiments were made in dogs under the conditions of blood autoperfusion of one of the left coronary artery branches. Chemical removal of the endothelium with saponin was shown to lead to abnormal coronary reactivity, eliminate dilatory and give rise to constrictive responses to ATP, acetylcholine, histamine. After an initial coronary dilatation, hypoxic hypoxia resulted in a pronounced increase in coronary resistance and a reduction in coronary flow in intact animals. Preliminary deendothelization of the coronary artery caused disappearance of a dilatatory phase of the reaction, acceleration and enhancement of coronary constriction in response to hypoxia.
ISSN:	0022-9040