Molecular genetic detection of polyclonal immune response in autoimmune thyroiditis and inflammatory bowel diseases

Southern blot hybridization techniques were used to analyze the arrangements of the immunoglobulin and the T cell antigen receptor genes in lymphocytes of patients with Graves disease and Hashimoto's thyroiditis as well as in patients with Crohn's disease, chronic ulcerative colitis, and w...

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Bibliographic Details
Published in:	Monatsschrift Kinderheilkunde Vol. 137; no. 9; p. 610
Main Authors:	Kaulfersch, W, Baker, J R, Burman, K D, Fiocchi, C, Ahmann, A J, D'Avis, J C, Waldmann, T A
Format:	Journal Article
Language:	German
Published:	Germany 01-09-1989
Subjects:	Adolescent Adult Blotting, Southern Child Cloning, Molecular Colitis, Ulcerative - genetics Colitis, Ulcerative - immunology Crohn Disease - genetics Crohn Disease - immunology Female Gene Rearrangement, beta-Chain T-Cell Antigen Receptor - genetics Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor - genetics Gene Rearrangement, T-Lymphocyte Graves Disease - genetics Graves Disease - immunology Humans Male Middle Aged Receptors, Antigen, T-Cell - genetics Thyroiditis, Autoimmune - genetics Thyroiditis, Autoimmune - immunology
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Summary:	Southern blot hybridization techniques were used to analyze the arrangements of the immunoglobulin and the T cell antigen receptor genes in lymphocytes of patients with Graves disease and Hashimoto's thyroiditis as well as in patients with Crohn's disease, chronic ulcerative colitis, and with other gastrointestinal disease. The results indicate that the immune response of autoimmune thyroid disease and inflammatory bowel disease is of polyclonal origin.
ISSN:	0026-9298