The role of endogenous regulators in the compensatory process after salivary gland resection

• Published in: Biulleten' eksperimental'noi biologii i meditsiny Vol. 103; no. 4; p. 473
• Main Authors: Denisov, A B, Pomerantseva, E N, Zotova, L A
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 01-04-1987
• Subjects: Acid-Base Equilibrium; Animals; Carbon Dioxide - blood; Isoenzymes; L-Lactate Dehydrogenase - blood; L-Lactate Dehydrogenase - metabolism; Male; Necrosis; Oxygen - blood; Rats; Regeneration; Submandibular Gland - metabolism; Submandibular Gland - pathology; Submandibular Gland - physiology
• ISSN: 0365-9615

The ways of penetration of submandibular salivary degeneration products into the blood after partial gland resection have been studied on 97 rats. Using isoenzyme LDH spectrum of the blood, as well as of gland and regional lymph node tissue, the acid-base balance values and morphological data, it has been shown that degeneration products of salivary glands penetrate into the general blood flow through regional lymph nodes, where they are partly modified. The true changes in LDH spectrum can be already registered half an hour after the injury of the gland. The influence of the degeneration products of gland tissue on the initiation of the compensation processes in cellular hyperplasia is discussed.