The renin-angiotensin system and large arteries in the hypertensive patient

The large arteries are impaired in uncomplicated, permanent, essential arterial hypertension. The peripheral arteries such as the humeral artery or the common carotid artery have a normal or increased diameter, reduced blood flow and, especially, reduced compliance. Reduction of the arterial complia...

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Bibliographic Details
Published in:	Annales de cardiologie et d'angéiologie Vol. 34; no. 10; p. 693
Main Authors:	Bouthier, J, Hugue, C, Asmar, R, Simon, A, Safar, M
Format:	Journal Article
Language:	French
Published:	France 01-12-1985
Subjects:	Angiotensin-Converting Enzyme Inhibitors Antihypertensive Agents - pharmacology Arteries - drug effects Arteries - enzymology Arteries - physiopathology Elasticity Hemodynamics Humans Hypertension - physiopathology Renin-Angiotensin System
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Summary:	The large arteries are impaired in uncomplicated, permanent, essential arterial hypertension. The peripheral arteries such as the humeral artery or the common carotid artery have a normal or increased diameter, reduced blood flow and, especially, reduced compliance. Reduction of the arterial compliance reflects an impairment peculiar to the large blood vessels, independent of the pressure. Antihypertensive medicines, for a given drop in pressure, may increase, diminish or not change arterial compliance. This is an important point to be taken into account in relation to cardiovascular morbidity and mortality of treated hypertensives. It has been particularly well studied in the context of inhibitors of the renin-angiotensin system.
ISSN:	0003-3928