Immunological disorders of homeostasis and the methods of their correction for the programmed and preoperative treatment of patients with nonspecific aorto-arteritis

• Published in: Hirurgija (Moskva) no. 5-6; p. 23
• Main Authors: Spiridonov, A A, Ambat'ello, S G, Samuilova, D Sh, Khurges, I S, Ivanova, L S, Dmitrieva, V A
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 01-05-1992
• Subjects: Adolescent; Adult; Aortitis - complications; Aortitis - immunology; Aortitis - therapy; Arteritis - complications; Arteritis - immunology; Arteritis - therapy; Child; Chronic Disease; Female; Hemoperfusion - instrumentation; Hemoperfusion - methods; Homeostasis - immunology; Humans; Immune System Diseases - etiology; Immune System Diseases - immunology; Immune System Diseases - therapy; Immunity, Cellular - immunology; Patient Care Planning; Phagocytosis - immunology; Preoperative Care
• ISSN: 0023-1207

The authors examined 29 patients with aorto-arteritis of unspecific origin of different duration and variants of affections of the major vessels. The patients were divided into groups with active and inactive course of the inflammatory process. The changes of immunological values and the phagocytosis data were more marked in the group with the active phase of the disease. These changes correlated with the data on unspecific inflammation and the clinical picture. Twenty-two patients were treated by hemosorption and immunocorrective measures. The fibrinogen concentration reduced, the ESR was normalized, and C-reactive protein became negative. The concentration of circulating immune complex and immunoglobulins diminished, the phagocytosis values became close to normal. It is concluded that hemosorption is an effective method of correction of immunological disorders in unspecific aorto-arteritis, both as an independent therapeutic method and as a measure of preoperative management.